Disease gene prioritization tool using protein-protein interaction network

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6.0 years ago

Swimming bird ▴ 20

Hello!

I'm searching a tool to perform a disease gene prioritization. I have a list of seed genes, which are related to a particular disease, and a candidate genes list which I want to prioritize to obtain a gene ranking. In addition, I have protein-protein interaction data.

The problem is that I can't find a tool which allows to load your own protein-protein interaction network. The only I found it's DaDa (http://compbio.case.edu/omics/software/dada/) but I don't have a license for MATLAB.

seed genes disease ppi gene prioritization • 1.2k views

ADD COMMENT • link updated 5.6 years ago by Michael 54k • written 6.0 years ago by Swimming bird ▴ 20

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Some of the gene prioritization algorithms can easily be implemented. See for example my tutorial here and application in this paper. The focus is on gene function but the principles can be applied to diseases. You can find a list of gene prioritization tools on omictools.com.

ADD REPLY • link 6.0 years ago by Jean-Karim Heriche 27k

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