Question: Measuring insertion/deletion frequency of a small sequence motif
gravatar for James Ashmore
22 months ago by
James Ashmore2.8k
UK/Edinburgh/MRC Centre for Regenerative Medicine
James Ashmore2.8k wrote:

I want to check how often the sequence TGAT is inserted or deleted in different strains of mouse. I downloaded VCF files containing SNPs and Indels for each strain from the Mouse Genomes Project. I can grep the indels file for my sequence and count how many times it appears in the REF/ALT columns. However, a single nucleotide change can also change the frequency. I was going to write a script to get the SNP coordinates and check if they were inside a TGAT sequence from the reference genome, but wanted to check if anyone knows or a tool which may answer my question, or even a better way to measure what I want?

mnp snp • 522 views
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