Measuring insertion/deletion frequency of a small sequence motif
0
0
Entering edit mode
6.0 years ago
James Ashmore ★ 3.4k

I want to check how often the sequence TGAT is inserted or deleted in different strains of mouse. I downloaded VCF files containing SNPs and Indels for each strain from the Mouse Genomes Project. I can grep the indels file for my sequence and count how many times it appears in the REF/ALT columns. However, a single nucleotide change can also change the frequency. I was going to write a script to get the SNP coordinates and check if they were inside a TGAT sequence from the reference genome, but wanted to check if anyone knows or a tool which may answer my question, or even a better way to measure what I want?

SNP MNP • 1.2k views
ADD COMMENT

Login before adding your answer.

Traffic: 2609 users visited in the last hour
Help About
FAQ
Access RSS
API
Stats

Use of this site constitutes acceptance of our User Agreement and Privacy Policy.

Powered by the version 2.3.6