Does anyone of you have experience with computing the variant distance bias (VDB) value for VCF-formatted files?
I am trying to figure out myself how to do it, but literature / documentation / discussion on it is quite scarce.
So far, what I know is:
- The higher the value, the bigger the bias is
- 0 = no bias
- It has to be a float
What is the range for such value? Does anyone have a ready-to-go formula to use? Are there any established rules of thumb that one can use to understand it?
I'm sorry if this question is trivial for someone, I'm a bit lost.
- The range is [0,1] as a likelihood