Question: Datasets containing post neoadjuvant therapy triple-negative breast cancer samples ?
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gravatar for oliver.hickman
11 months ago by
oliver.hickman0 wrote:

Does anyone know of studies or datasets that feature samples from patients following neoadjuvant therapy in breast cancer?

Specifically I am looking for profiles of tumours post-treatment that have relapsed. Most interested in triple negative samples.

Thanks

ADD COMMENTlink modified 11 months ago by Kevin Blighe41k • written 11 months ago by oliver.hickman0
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gravatar for Kevin Blighe
11 months ago by
Kevin Blighe41k
Guy's Hospital, London
Kevin Blighe41k wrote:

I have data from the neoadjuvant setting in breast cancer, but most ER-positive cases, and not yet published. For triple negative breast cancer (TNBC), I found a few datasets, but most microarray-based gene expression:

There appears to also be TNBC-specific studies under the ICGC, too. If you take a look at the European Genome-phenome Archive (EGA), you'll find them, like, for example, this one: https://www.ebi.ac.uk/ega/studies/EGAS00001000092

There is also some TNBC samples in the TCGA data. You can infer TNBC status by following my methodology, here: How to download triple negative breast cancer RNA-seq fpkm data from GDC.

Kevin

ADD COMMENTlink written 11 months ago by Kevin Blighe41k
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