Are there needs to perform imputation for genotype generated from WGS ?
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3.5 years ago
hxlei613 ▴ 90

I know imputation is usually performed for genotypes from chips. What if these genotypes are from WGS ? It's true that WGS is expensive for a huge population. WHat about your opinions ?

imputation WGS • 973 views
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3.5 years ago
YaGalbi ★ 1.5k

This paper provides a method and a good discussion on this topic involving imputation to reduce cost of genotyping large cohorts.

Whole-genome characterization in pedigreed non-human primates using genotyping-by-sequencing (GBS) and imputation

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