For my research I am attempting to find common transcription factors for a set of genes by comparing their transcription factor binding sites in their promoters. I am not a bioinformatician and am not familiar with most of these resources. I am simply asking if this tool can do this task once I become more familiar with it.
If you don't have a bioinformatics background, then online tools like Enrichr can be quite useful, I'm sure. Enrichr merely 'mines' other popular databases that are typically used by bioinformaticians, in particular, databases that hold information on TF and micro-RNA interactions. JASPAR and TRANSFAC, for example, are quite popular and are updated regularly (I'm not sure if enrichr takes a snapshot in time of these databases or mines them directly each time, though). I see some other resources used by enrichr that are older and which may no longer be relevant as technologies have improved.
If you literally just want to see which TFs target your genes of interest, then just take the statistically significant results from the TRANSFAC and JASPAR PWMs part of the results. I'm not sure that anyone can criticse the results of these. You should additionally check the documentation to see which of the other databases may be of relevance. For example, ChEA appears to hold data on TF binding in different cell-lines. Tissue specificity may be quite relevant to your particular experiment.
Thank you so much! I really appreciate your explanation!
No problem, Mo!