Question: How to interpret ChIP-seq peak at cell line level?
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gravatar for Yijun Tian
2.0 years ago by
Yijun Tian20
Medical College of Wisconsin
Yijun Tian20 wrote:

Hello everyone,

I have a list of enriched peaks called from rigorous prepared ChIP-seq reads obtained by certain treatment which can activate specific transcription factor. The headers are: 1. RegionID 2. chr 3. start 4. end 5. -log10 q-value (QuEST) 6. -log10 p-value (QuEST) 7. Rank 8. ChIP reads 9. High confidence peaks

My question is:

  1. Can we interpret the "Rank" for genomic regions in the list as their affinity to the interest TF across genome.
  2. If yes for question 1, are there any widely accepted models describing the binding order for the interest TF when its concentration or activity gradually increases.

Thanks in advance!

chip-seq • 530 views
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