Modeling Transcription Factor-DNA binding

Question

[justinms]

I know there are probabilistic models used to determine whether or not a Transcription factor will bind a given DNA sequence but I would like to know given a particular protein sequence the strength or the binding affinity to which it binds its consensus sequence. Are there any algorithms or programs that give this output?

Essentially, I have protein mutations and I wish to know if these mutations increase/decrease the proteins ability to bind a particular DNA seq.