How to determine a single copy gene ?

Question

[Yongwang Zhang]

I want to classify single copy genes and duplicate genes in whole Human genome . But I do not find a good way to solve this problem.

[WouterDeCoster]

But I do not find a good way to solve this problem.

It's good practice to tell us what you tried, we will be more eager to put you on the right track if you show some effort, or can point out what went wrong in your approach.

Answer 1

[Emily]

BioMart query to get all genes without paralogues.

BioMart query to get all genes which have one or more paralogues.

Answer 2

[Carambakaracho]

Rreciprocal best blast hits is one good way to do this. Blast each gene against all genes and compare the results of the best hit. See the work done in Koonin's group in the early 2000s (e.g. https://www.ncbi.nlm.nih.gov/pubmed/12969510) or the EggNOG database http://eggnogdb.embl.de/#/app/home