What tool should be used to determine IDR or Np/Nt and N1/N2 between ChIP-seq samples?
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3.8 years ago
salamandra ▴ 460

I wanted to calculate IDR (irreproducible discovery rate) between two ChIP-seq samples to determine significant peaks (with IDR < 1%). Came across this R package 'IDR', but, as explained here, first would have to make sure IDR can be applied, i.e. Np/Nt < 2 and N1/N2 < 2. Is there any tool that can calculate Np/Nt and N1/N2? Which tools do you ususally use to determine IDR?

ChIP-Seq IDR ENCODE • 1.3k views
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