Sequence specific bias for reverse transcriptase

Question

[rnaseqbias]

Are there any known sequence-specific bias for reverse transcriptase? I am interested in the bias that may arise in the first strand cDNA synthesis step of RNA-Seq library preparation. Thank you.

[h.mon]

Yes there are:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2896536/