TCGA provide a molecular classification (Luminal A , Luminal B, Basal, Normal like, HER2 enriched) Basal subtype can be divided in basal A and basal B. (Kao et al., 2009; Neve et al., 2006) It has been done using expression from MicroArray via Significance Analysis of Microarrays (SAM) or PAM using the nearest shrunken centroid methodology. I retrieved from the paper a gene list used to classify so I have some ideas to begin to work but I was wondering if there ware a more standard approach to do that using TPM gene expression values.
Question: How to define Basal B subtype from TCGA breast cancer patient samples ?
24 months ago by
ZheFrench • 300
ZheFrench • 300 wrote:
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