what is gc bias?
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3.3 years ago
cilgaiscan ▴ 50

Hi people! What exactly we can say about GC bias in sequencing/mapping? how can we understand it?

gc bias gc bias sequencing mapping • 7.8k views
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Hi cilgaiscan, what exactly do you want to know? Did you search for information? There is a huge body of work, both formal - like papers - and "informal" - like foruns and blog posts. Some links:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4053816/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3639258/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378858/

http://seqanswers.com/forums/showthread.php?t=16114

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This sounds a bit like an assignment/homework question - is it?

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a badly posed one, though ;)

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3.3 years ago

Assuming you're referring to PCR-based sequencing, see Benjamini & Speed

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