Mice driver mutations

Question

[Gene_MMP8]

I have 10 normal-tumor paired genomes of mice suffering from pancreatic cancer. I have started doing the usual NGS analysis of checking the quality of bam reads, calling variants and annotating them. Now I want to find driver mutations and subsequently driver genes from the samples. Now, most of the driver identification tools are based on human genomes. Can you suggest a tool that works for non-human (esp. mice) genomes as well?SIFT driver mutation

Answer 1

[sophiespo]

If you're happy to look at CNV as a driving cause of pancreatic cancer, you can use GISTIC2.0 to work on mouse samples and find significant regions of loss and gain. I did this successfully for a mesothelioma mouse model.