Question: Mice driver mutations
gravatar for banerjeeshayantan
2.4 years ago by
banerjeeshayantan190 wrote:

I have 10 normal-tumor paired genomes of mice suffering from pancreatic cancer. I have started doing the usual NGS analysis of checking the quality of bam reads, calling variants and annotating them. Now I want to find driver mutations and subsequently driver genes from the samples. Now, most of the driver identification tools are based on human genomes. Can you suggest a tool that works for non-human (esp. mice) genomes as well?SIFT driver mutation

ADD COMMENTlink modified 2.4 years ago by sophiespo90 • written 2.4 years ago by banerjeeshayantan190
gravatar for sophiespo
2.4 years ago by
sophiespo90 wrote:

If you're happy to look at CNV as a driving cause of pancreatic cancer, you can use GISTIC2.0 to work on mouse samples and find significant regions of loss and gain. I did this successfully for a mesothelioma mouse model.

ADD COMMENTlink written 2.4 years ago by sophiespo90
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