Hi so Im doing some motif searches and was hoping to get some clarification on how these programs work. When running AME on a set of 250 sequences I get a certain number of hits back and for one specific motif/PWM it was present in 16 of the fasta sequences with some of those being true positive hits and some being true false positive. However when running the same exact PWM against the same sequences through FIMO it found 51 occurrences of this motif, wondering how they differ in this sense? Thanks!
Question: FIMO vs AME - true positive and false positives across search tools
22 months ago by
rbronste • 360
rbronste • 360 wrote:
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