I have had concern for the relationship of these three terms for long time...
My understanding is that
1: For a specific cancer type, mutant 'A' could be its one of many driver genes. On the ohter hand, mutant 'A' must has high sensitivity and specificity to that cancer type to be its biomarker (Not sure if both sensitivity and specificity needed?). Seems like biomarker and driver has some overlap, like IDH1 as both driver gene and biomarker for glioma.
2: The discovery of driver mutation / biomarker is usually initiated from identifying recurrent mutations. Seems like this is for now the only way to discover driver mutation / biomarker although, in my opinion, driver mutation / biomarker does not has to be current.
3: There are many driver gene prediction tools. Anyone has recommendation of thich one to use?
I am sure I missed some good points about driver mutation / biomarker. Can anyone share some comments?