Discrepancy in Copy Number Alteration between different cancer stages
1
0
Entering edit mode
3.7 years ago

Dear all,

I am studying copy number alterations in different stages of cancer.

I expected to see the alteration of stage i in stage ii and the next other stages. I think that the copy number alterations must be remained in the next stages. However it is not true and I cannot understand the underlying biological reason for this.

Could you please explain me the reason?

Nazanin

copy number alteration cancer stages • 688 views
ADD COMMENT
0
Entering edit mode
3.7 years ago
thomaskuilman ▴ 820

I assume that you mean copy number alterations in different stages of cancer in the same patient? You may find such differences for several reasons. For instance, alterations may be gained or lost as a consequence of the evolutionary pressure in the tumor. Also, it might be that the tumors arose completely independently, or that they have a common 'ancestor' tumor cell, but evolved independently from thereon.

ADD COMMENT

Login before adding your answer.

Traffic: 875 users visited in the last hour
Help About
FAQ
Access RSS
API
Stats

Use of this site constitutes acceptance of our User Agreement and Privacy Policy.

Powered by the version 2.3.6