Question: Calling CNVs from WGS data
gravatar for CH
11 days ago by
CH0 wrote:

Hi all,

I want to do some whole-genome sequencing to validate CNVs and identify breakpoints for CNVs call by array data. I've been having a bit of a look around but I can't seem to find a consensus on the depth required to call CNVs accurately. Does anyone have any experience or advice on this?

ADD COMMENTlink modified 11 days ago by Chris Miller20k • written 11 days ago by CH0
gravatar for Chris Miller
11 days ago by
Chris Miller20k
Washington University in St. Louis, MO
Chris Miller20k wrote:

It depends on the resolution that you need, but I've called CNVs (fairly large scale) from 1x coverage or less. If you need exact breakpoints, you'll probably need substantially more.

ADD COMMENTlink written 11 days ago by Chris Miller20k
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