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Question: Calling CNVs from WGS data
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gravatar for CH
4 months ago by
CH • 0
CH • 0 wrote:

Hi all,

I want to do some whole-genome sequencing to validate CNVs and identify breakpoints for CNVs call by array data. I've been having a bit of a look around but I can't seem to find a consensus on the depth required to call CNVs accurately. Does anyone have any experience or advice on this?
bioinformatics cnv sequencing wgs sv • 233 views
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modified 4 months ago by Chris Miller ♦ 20k • written 4 months ago by CH • 0
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gravatar for Chris Miller
4 months ago by
Chris Miller ♦ 20k
Washington University in St. Louis, MO
Chris Miller ♦ 20k wrote:

It depends on the resolution that you need, but I've called CNVs (fairly large scale) from 1x coverage or less. If you need exact breakpoints, you'll probably need substantially more.
ADD COMMENT • link written 4 months ago by Chris Miller ♦ 20k
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