**50**wrote:

Hi all,

I am looking to calculate the frequencies of all possible combinations of a group of SNP genotypes, in a population. This would be done based on the minor allele frequencies acquired in our population data. I just have a question on whether the following is the right way to do it:

If for example, we have three SNPs, their alleles, and their minor allele frequencies, with A2 being the minor allele:

```
SNP A1 A2 MAF
SNPA A T 0.1
SNPB C G 0.3
SNPC A G 0.4
```

And I now have compiled the possible genotype combinations from the three SNPs:

```
AA-CC-AA
AA-CC-AG
AA-CG-AA
AA-CG-AG
...
```

and so on for 27 combinations.

In order to calculate the frequencies of each 'profile', would I simply multiply all the allele frequencies? For example, the first AA-CC-AA frequency would be:

```
(0.9)(0.9) x (0.7)(0.7) x (0.6)(0.6)
```

While for the AA-CC-AG combination it would be:

```
(0.9)(0.9) x (0.7)(0.7) x (0.6)(0.4)
```

Would this be correct?

Thanks!

**90**• written 9 months ago by Volka •

**50**