Question: Mutations to use in mutational signature analysis
0
gravatar for jc
5 months ago by
jc0
jc0 wrote:

When performing mutational signature analysis with R packages such as deconstructSigs and SomaticSignatures, should all SNVs be used or just nonsilent SNVs?

mutational signatures • 237 views
ADD COMMENTlink modified 5 months ago by Kevin Blighe39k • written 5 months ago by jc0
0
gravatar for Kevin Blighe
5 months ago by
Kevin Blighe39k
Republic of Ireland
Kevin Blighe39k wrote:

I believe the choice is yours. It would make intuitive sense to include missense mutations, though, and not intronic or intergenic variants. Basically, you use whatever you want to use.

Kevin

ADD COMMENTlink written 5 months ago by Kevin Blighe39k
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