Question: Mutations to use in mutational signature analysis
0
gravatar for jc
13 months ago by
jc0
jc0 wrote:

When performing mutational signature analysis with R packages such as deconstructSigs and SomaticSignatures, should all SNVs be used or just nonsilent SNVs?

mutational signatures • 605 views
ADD COMMENTlink modified 13 months ago by Kevin Blighe51k • written 13 months ago by jc0
0
gravatar for Kevin Blighe
13 months ago by
Kevin Blighe51k
Kevin Blighe51k wrote:

I believe the choice is yours. It would make intuitive sense to include missense mutations, though, and not intronic or intergenic variants. Basically, you use whatever you want to use.

Kevin

ADD COMMENTlink written 13 months ago by Kevin Blighe51k
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