Question: How plink calculates meta-analysis
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gravatar for johnS
24 months ago by
johnS10
johnS10 wrote:

I am trying to find the logic/calculation what is used in plink to calculate the meta analysis when run the following command

plink --meta-analysis study1.assoc study2.assoc study3.assoc

I checked the plink website but dint find details http://zzz.bwh.harvard.edu/plink/metaanal.shtml . Could someone help me with the calculations that are happening in plink to come up with that single file after meta analysis ?

plink meta-analysis metal gwama • 1.3k views
ADD COMMENTlink modified 23 months ago by Biostar ♦♦ 20 • written 24 months ago by johnS10

From the plink 1.9 website:

Given multiple PLINK-format association reports, --meta-analysis performs basic fixed-effects and random-effects meta-analysis of the data, writing results to plink.meta.

ADD REPLYlink modified 23 months ago • written 23 months ago by zx87549.7k
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