How plink calculates meta-analysis
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3.0 years ago
johnS ▴ 10

I am trying to find the logic/calculation what is used in plink to calculate the meta analysis when run the following command

plink --meta-analysis study1.assoc study2.assoc study3.assoc

I checked the plink website but dint find details http://zzz.bwh.harvard.edu/plink/metaanal.shtml . Could someone help me with the calculations that are happening in plink to come up with that single file after meta analysis ?

meta-analysis plink metal gwama • 2.1k views
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From the plink 1.9 website:

Given multiple PLINK-format association reports, --meta-analysis performs basic fixed-effects and random-effects meta-analysis of the data, writing results to plink.meta.

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