Im new to bioinformatics and trying to figure out log 2 FC..

i have a log 2 fold values of a parts of a gene in full sequence which is listed below using micro arrays. log2-fold change -0.611040 -0.583231 -0.495397 -0.462919 0.412907 0.405912 which goes on

does negative value mean down regulation and positive valuse mean up regulation ?? like the values with 0 ,1 or -1

yes i did...i was trying to find out what does positive and negative value of log2FC mean.

Imagine you are calculating fold-change by measuring counts ratios, so:

Here,

FoldChangevalues larger than one means the gene is more expressed inTreatment, aFoldChangeof exactly one means no difference, andFoldChangevalues between zero and one means the gene is more expressed inControl. Now, if you take the log base 2 of the FoldChange values, you will have:So positive values means the gene is more expressed in

Treatment, and negative values means the gene is more expressed inControl.thank you for the reply...it really helped..