Question: Heritability Atlas Based on Twins Study
3
gravatar for Shicheng Guo
29 days ago by
Shicheng Guo7.3k
Shicheng Guo7.3k wrote:

Hi All,

Anyone knows is there any paper provided the Heritability (h2) to large number of human phenotypes with twin's data?

or any database to show the h2 for different phenotypes/traits?

Thanks.

Update: done!

@Fabio Marroni give me exactly what I want. Thanks.

Heritability of >2,000 traits & disorders in UK Biobank https://nealelab.github.io/UKBB_ldsc/


If heritability provides such limited information, why do researchers study it? Heritability is of particular interest in understanding traits that are very complex with many contributing factors. Heritability can give initial clues as to the relative influences of “nature” (genetics) and “nurture” (environment) on complex traits, and it can give researchers a place to start teasing apart the factors that influence these traits.

twins heritability • 126 views
ADD COMMENTlink modified 25 days ago by Biostar ♦♦ 20 • written 29 days ago by Shicheng Guo7.3k
1

Not twin data, not a database, but I estimated heritability for 43 QTs in humans. This is the link to the paper, where you can find plenty of references to other works estimating heritability for human QTs. I am not aware of any database, but there might be something around.

ADD REPLYlink written 29 days ago by Fabio Marroni2.0k
1

Great work!! UK biobank don't have the estimation?

ADD REPLYlink written 29 days ago by Shicheng Guo7.3k
1

Indeed they do, and they have great results! Give a look here!

ADD REPLYlink written 29 days ago by Fabio Marroni2.0k
1

Can you download the h2 result? I cannot download....

ADD REPLYlink written 29 days ago by Shicheng Guo7.3k
1

It is SNP-heritability, why they don't have twin based heritability. They have have such data, right?

ADD REPLYlink written 27 days ago by Shicheng Guo7.3k
1

There are two sets of data:

The file ukbb_all_h2part_results.txt.gz gives an error 415, but I was able to download the file ukbb_all_h2univar_results.txt.gz.

I don't know the difference between the two. You might contact the maintainers regarding the first file.

ADD REPLYlink written 28 days ago by Fabio Marroni2.0k
4
gravatar for Fabio Marroni
26 days ago by
Fabio Marroni2.0k
Italy
Fabio Marroni2.0k wrote:

They have a population-based sample, so I think they do not have twin-based heritability. If you need twin data you might look for twin-based registries such as this one.

ADD COMMENTlink modified 26 days ago • written 26 days ago by Fabio Marroni2.0k
1

Great. Thanks again!!

ADD REPLYlink written 25 days ago by Shicheng Guo7.3k

Moved this post to an answer since it seems to have provided closure to the thread. Please go ahead and accept it if you're happy with the resolution @Shicheng

ADD REPLYlink written 25 days ago by jrj.healey9.1k
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