Entering edit mode
5.4 years ago
Gina
▴
10
Hi,
How can I find conserved domains in a protein sequece, and why are some sequences conserved and some not? Which useful tools can you recommend to find conserved domains?
This sounds like a homework/assignment question. If that's the case, it will be closed as off-topic unless you first show us your efforts to tackle the questions. We will be happy to steer you in the right direction after that.
Your question is too general. What organism you are interested in?
Prokaryotic or eykaryotic one?
There are a lot of posts in Biostars about protein domains.
Just go to the left-hand upper corner, click
'LATEST' and type your question (conserved domains in a protein sequence)
to an empty string in the middle of the page. But add some details. I've found several links,
but I am not sure this will help you a lot - they are also general.
Also look at the right panel - there may be very recent threads as well.
Uniprot – is a good sourse:
Conserved Domain Batch Retrieval
pfam and hmm databse of PFAM
protein domain software
PROSITE and ConPlex
A: Tool For Evolutionary Conservation Of Protein Folds
Domain prediction
How can find conserved domains of protein's sequence offline?
domains from multiple sequences
Extract Domain Sequences From Multiple Sequences
Protein domain visualization tools
Looking for a protein domain visualisation tool