Hi Every one
I am a bit stuck at this error from Michigan Imputation Server, does any one know what this error means and any hint to fix?
Error: More than 100 obvious strand flips have been detected. Please check strand. Imputation cannot be started!
Statistics: Alternative allele frequency > 0.5 sites: 0 Reference Overlap: 99.80% Match: 426,485 Allele switch: 66,772 Strand flip: 23,263 Strand flip and allele switch: 13,805 A/T, C/G genotypes: 642 Filtered sites: Filter flag set: 0 Invalid alleles: 0 Duplicated sites: 286 NonSNP sites: 0 Monomorphic sites: 0 Allele mismatch: 465 SNPs call rate < 90%: 0