Question: How can I tell if there is CNV for specific gene in IGV?
0
gravatar for Pin.Bioinf
12 weeks ago by
Pin.Bioinf230
Malaga
Pin.Bioinf230 wrote:

Hello,

I am wondering if there is a way to visualize the CNV ratio for a specific gene in IGV and how can I visualize it. If not, how can I obtain the CNV ratio?

Thank you!

igv cnv • 198 views
ADD COMMENTlink modified 12 weeks ago by Vitis1.9k • written 12 weeks ago by Pin.Bioinf230
2
gravatar for Vitis
12 weeks ago by
Vitis1.9k
New York
Vitis1.9k wrote:

If you are using Illumina data for CNV discovery, there usually are two things you'll be looking for: coverage changes and breakpoints. Clean and clear-cut copy number changes are easy to spot on a coverage plot with distinct breakpoints from IGV or any other genome browser that supports BAM coverage. If you don't know where to look, coverage in sliding windows could be calculated and compared to find abnormal coverage changes standing out of normal coverage fluctuation noise.

ADD COMMENTlink written 12 weeks ago by Vitis1.9k
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