Forum: Tool for miRNA target prediction and translation from mouse to human?
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gravatar for passi.g
11 weeks ago by
passi.g0
passi.g0 wrote:

I'am just wondering if anybody would be interested in a tool were you can easily access miRNA target prediction and do the translation from mouse data to human data.

We recently puplished a paper in Molecular Metabolism in regards to miRNA target prediction but only in mice: "A computational biology approach of a genome-wide screen connected miRNAs to obesity and type 2 diabetes"

With a online tool available: https://146.107.176.32/miR-QTL-Scan/

We were now wondering if the community would be interested in a more generall tool.

Including:

  1. miRNA target prediction (combined with tissue specific gene expression)
  2. Pathway enrichment (of targets)
  3. Genetic variants (QTL / GWAS)
  4. Chip-SEQ (included from ENCODE)

The main aspect would be the possibility to translate interesting mouse miRNA directly in context to human:

  1. Conservation of miRNA
  2. Conservation of miRNA binding seed in mRNA
  3. Could this miRNA be linked to a GWAS

I guess there are still more possibilitys to integrate more data, but we are not sure how interested other scientists are on such a tool.

I hope somebody will give feedback if this would be indeed usefull for other scientists.

ADD COMMENTlink written 11 weeks ago by passi.g0
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