Question: Breast oncoprotein oncogene
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gravatar for BabySteps
4 months ago by
BabySteps0
BabySteps0 wrote:

Where can I find the complete list/database of breast cancer genes and proteins?

ADD COMMENTlink modified 4 months ago by Nicolas Rosewick7.5k • written 4 months ago by BabySteps0

There is no need to SHOUT. I have adapted your title to remove the capital characters.

ADD REPLYlink written 4 months ago by WouterDeCoster38k
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gravatar for Michael Dondrup
4 months ago by
Bergen, Norway
Michael Dondrup46k wrote:

I am not sure if there can be a complete list or database of Breast cancer genes anywhere, but this article from 2012 contains genes containing driver mutations: https://www.nature.com/articles/nature11017

Then there is of course the COSMIC database. https://cancer.sanger.ac.uk/cosmic Now if you search there for 'breast cancer' with a query like this: https://cancer.sanger.ac.uk/cosmic/browse/tissue?hn=carcinoma&in=t&sh=NS&sn=breast&ss=NS

A better gene set might be retrieved by going to the COSMIC gene census: https://cancer.sanger.ac.uk/cosmic/census?tier=all

and filtering the gene list for 'breast' (723 hits)

You receive over 24000 genes with mutations in one or the other sample. Most of them I propose are passenger mutations, see also: Driver And Passenger Mutations In Cancer

I believe that for a small number of known genes that is constantly expanded and changed, you will be better served by doing a comprehensive literature search through PubMed etc first. The task is to stay aligned with the current state of research and of course find more recent publications than the one I gave first:

ADD COMMENTlink modified 4 months ago • written 4 months ago by Michael Dondrup46k
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