Question: How to calculate Polygenic Risk Score from Summary Results with Z-Score only
1
gravatar for AnnaStieber
14 months ago by
AnnaStieber10
AnnaStieber10 wrote:

I have summary results from a large GWAS. The information given in this summary statistics is the following columns:

Chromosome, Position, Markername, Effect_allele, Other_allele, P-value , Zscore.

If i understood it correctly, the Z-score is the standardized effect measure (effect/StdError). Is there a way to create a PRS based on this Zscore instead of based on the original effect-estimates? Or do i have to estimate the beta from the Zscore in any way (by using allele frequency,..)? Has anyone done this before? All advice is appreciated!

ADD COMMENTlink modified 13 months ago by Sam2.6k • written 14 months ago by AnnaStieber10
2
gravatar for Sam
13 months ago by
Sam2.6k
New York
Sam2.6k wrote:

You can use the z-score for PRS calculation as long as your target and base are from the same population.

ADD COMMENTlink written 13 months ago by Sam2.6k
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