Question: How to calculate Polygenic Risk Score from Summary Results with Z-Score only
gravatar for AnnaStieber
4 months ago by
AnnaStieber0 wrote:

I have summary results from a large GWAS. The information given in this summary statistics is the following columns:

Chromosome, Position, Markername, Effect_allele, Other_allele, P-value , Zscore.

If i understood it correctly, the Z-score is the standardized effect measure (effect/StdError). Is there a way to create a PRS based on this Zscore instead of based on the original effect-estimates? Or do i have to estimate the beta from the Zscore in any way (by using allele frequency,..)? Has anyone done this before? All advice is appreciated!

ADD COMMENTlink modified 3 months ago by Sam2.3k • written 4 months ago by AnnaStieber0
gravatar for Sam
3 months ago by
New York
Sam2.3k wrote:

You can use the z-score for PRS calculation as long as your target and base are from the same population.

ADD COMMENTlink written 3 months ago by Sam2.3k
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