How to calculate Polygenic Risk Score from Summary Results with Z-Score only
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Entering edit mode
2.4 years ago
AnnaStieber ▴ 10

I have summary results from a large GWAS. The information given in this summary statistics is the following columns:

Chromosome, Position, Markername, Effect_allele, Other_allele, P-value , Zscore.

If i understood it correctly, the Z-score is the standardized effect measure (effect/StdError). Is there a way to create a PRS based on this Zscore instead of based on the original effect-estimates? Or do i have to estimate the beta from the Zscore in any way (by using allele frequency,..)? Has anyone done this before? All advice is appreciated!

PRS GRS Risk Score Polygenic Risk Score Z-Score • 1.9k views
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Entering edit mode
2.3 years ago
Sam ★ 3.5k

You can use the z-score for PRS calculation as long as your target and base are from the same population.

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