Question: How to calculate Polygenic Risk Score from Summary Results with Z-Score only
1
gravatar for AnnaStieber
22 months ago by
AnnaStieber10
AnnaStieber10 wrote:

I have summary results from a large GWAS. The information given in this summary statistics is the following columns:

Chromosome, Position, Markername, Effect_allele, Other_allele, P-value , Zscore.

If i understood it correctly, the Z-score is the standardized effect measure (effect/StdError). Is there a way to create a PRS based on this Zscore instead of based on the original effect-estimates? Or do i have to estimate the beta from the Zscore in any way (by using allele frequency,..)? Has anyone done this before? All advice is appreciated!

ADD COMMENTlink modified 21 months ago by Sam3.2k • written 22 months ago by AnnaStieber10
2
gravatar for Sam
21 months ago by
Sam3.2k
New York
Sam3.2k wrote:

You can use the z-score for PRS calculation as long as your target and base are from the same population.

ADD COMMENTlink written 21 months ago by Sam3.2k
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