Question: How to calculate Polygenic Risk Score from Summary Results with Z-Score only

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AnnaStieber •

**10**wrote:I have summary results from a large GWAS. The information given in this summary statistics is the following columns:

Chromosome, Position, Markername, Effect_allele, Other_allele, P-value , Zscore.

If i understood it correctly, the Z-score is the standardized effect measure (effect/StdError). Is there a way to create a PRS based on this Zscore instead of based on the original effect-estimates? Or do i have to estimate the beta from the Zscore in any way (by using allele frequency,..)? Has anyone done this before? All advice is appreciated!

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modified 2.0 years ago
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Sam •

**3.3k**• written 2.1 years ago by AnnaStieber •**10**