Question: What is Genome-sequencing?
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gravatar for ashishbansal12300
15 months ago by
ashishbansal123000 wrote:

Genome-sequencing studies indicate that all humans carry many genetic variants predicted to cause loss of function (LoF) of protein-coding genes, suggesting unexpected redundancy in the human genome. Here we apply stringent filters to 2951 putative LoF variants obtained from 185 human genomes to determine their true prevalence and properties. We estimate that human genomes typically contain ~100 genuine LoF variants with ~20 genes completely inactivated. We identify rare and likely deleterious LoF alleles, including 26 known and 21 predicted severe disease–causing variants, as well as common LoF variants in nonessential genes. We describe functional and evolutionary differences between LoF-tolerant and recessive disease genes and a method for using these differences to prioritize candidate genes found in clinical sequencing studies.

genome • 321 views
ADD COMMENTlink written 15 months ago by ashishbansal123000

Hi ashishbansal12300

Before we take down this post, we want to understand the objective behind this.

ADD REPLYlink modified 15 months ago • written 15 months ago by lakhujanivijay4.8k

I believe the user has copied the text from a manuscript and pasted here and trying to figure out the term "Genome Sequencing" in that text mean!!

ADD REPLYlink written 15 months ago by karthic100

If that's the case, then OP needs to re frame the question.

ADD REPLYlink written 15 months ago by lakhujanivijay4.8k
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