Entering edit mode
5.2 years ago
Richard
▴
590
Hi folks,
We have thousands of BAM files aligned with BWA 0.7.6a that we now want to compress with CRAM. We're noticing that a subset of aligned reads will have a different MD tag after CRAM compression/decompression than they had in the original file.
The differences seem to be that some sequences that used to be reported on one strand are now reported on the other.
Is there any information out there that would indicate which, if any, analysis tools would yield different results now that the MD tags appear different ?
