**160**wrote:

Hi everyone,

I am doing the PRS with PRSice, I set as follow

```
...
--lower 0 \
--interval 0.01 \
--upper 0.85 \
...
```

the result in the *.prsice* is as follow

```
Set Threshold R2 P Coefficient Standard.Error Num_SNP
Base 0.11 0.0573236 2.14869e-05 1.41723 0.323538 1
Base 0.16 0.0820505 2.23083e-07 2.28802 0.42246 2
Base 0.23 0.124923 3.67078e-11 3.3304 0.468058 3
Base 0.44 0.212734 5.69775e-21 6.80455 0.624526 10
Base 0.46 0.225492 1.00129e-22 7.28094 0.631047 12
Base 0.57 0.223171 2.12793e-22 7.39902 0.647995 13
Base 0.6 0.238986 1.0476e-24 8.42251 0.68701 21
Base 0.62 0.244352 1.56133e-25 9.09485 0.724074 27
Base 0.7 0.251666 1.06589e-26 9.4993 0.731542 31
Base 0.76 0.2574 1.20287e-27 10.3398 0.775632 44
Base 0.77 0.265801 4.31103e-29 12.4527 0.898506 116
Base 0.78 0.265607 4.6651e-29 12.4531 0.899346 117
Base 0.79 0.26775 1.9452e-29 12.616 0.902045 122
Base 0.81 0.268386 1.49709e-29 12.6483 0.901663 123
Base 0.82 0.268006 1.75044e-29 12.659 0.904032 124
Base 0.83 0.266628 3.07871e-29 12.6872 0.911902 131
Base 0.84 0.269101 1.11373e-29 12.9602 0.920808 146
Base 0.85 0.274744 1.0325e-30 13.4441 0.9301 171
Base 1 0.292076 3.96269e-34 118.58 7.54246 110070
```

I wonder why even though I have set the parameters as above the threshold jump is not as expected `0 - 0.01 - 0.02 - ... - 0.85`

. Does any know what happens with it?

Your help is really appreciated!

**2.5k**• written 11 months ago by landscape95 •

**160**