Question: Differential expressed genes for GRN
gravatar for marwwa11
11 weeks ago by
marwwa110 wrote:

Hi biostars, please after doing the differnetial expression analysis between 2 conditions (cell type 1 vs cell type 2)using limma, I will have a list of significant genes. If I am interested to GRN in the cell 1 (the cell 2 is used just for the analysis,) so I must take only the genes up expressed in this cell or all the DEG genes? Sorry for this banal question. Thanks

rna-seq limma grn • 192 views
ADD COMMENTlink modified 11 weeks ago by Kevin Blighe41k • written 11 weeks ago by marwwa110
gravatar for Kevin Blighe
11 weeks ago by
Kevin Blighe41k
Guy's Hospital, London
Kevin Blighe41k wrote:

To avoid ambiguity, please don't use undefined acronyms. By 'GRN', I presume that you mean gene regulatory network? The information about up- and down-regulated genes are just as important as each other for a network analysis, i.e., cell-types can be equally defined as what is expressed as what is not expressed.


ADD COMMENTlink written 11 weeks ago by Kevin Blighe41k

Ok, thank you very much

ADD REPLYlink written 9 weeks ago by marwwa110
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