Question: Differential expressed genes for GRN
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gravatar for marwwa11
12 months ago by
marwwa110
marwwa110 wrote:

Hi biostars, please after doing the differnetial expression analysis between 2 conditions (cell type 1 vs cell type 2)using limma, I will have a list of significant genes. If I am interested to GRN in the cell 1 (the cell 2 is used just for the analysis,) so I must take only the genes up expressed in this cell or all the DEG genes? Sorry for this banal question. Thanks

rna-seq limma grn • 360 views
ADD COMMENTlink modified 12 months ago by Kevin Blighe54k • written 12 months ago by marwwa110
0
gravatar for Kevin Blighe
12 months ago by
Kevin Blighe54k
Kevin Blighe54k wrote:

To avoid ambiguity, please don't use undefined acronyms. By 'GRN', I presume that you mean gene regulatory network? The information about up- and down-regulated genes are just as important as each other for a network analysis, i.e., cell-types can be equally defined as what is expressed as what is not expressed.

Kevin

ADD COMMENTlink written 12 months ago by Kevin Blighe54k

Ok, thank you very much

ADD REPLYlink written 12 months ago by marwwa110
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