Question: Random SNPs simulation?
1
gravatar for thomasbersez
15 months ago by
thomasbersez50
Genevia Technologies, Finland
thomasbersez50 wrote:

Hi everyone,

For an allele mining project I need to generate in silico NGS data. I have chosen to use Grinder to do so. I would like to add randomly generated SNPs to my reference genome, is any software available to do that ?

Thanks for help!

snp • 803 views
ADD COMMENTlink modified 16 days ago by srikanthvarsha1110 • written 15 months ago by thomasbersez50

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5
gravatar for jean.elbers
15 months ago by
jean.elbers1.4k
jean.elbers1.4k wrote:

You could try mutate.sh from BBTools/BBMap. mutate.sh can also produce a VCF file of the SNPs added. You can also generate random Illumina reads with the BBTool randomreads.sh https://sourceforge.net/projects/bbmap/

ADD COMMENTlink modified 15 months ago • written 15 months ago by jean.elbers1.4k
2
gravatar for Corentin
15 months ago by
Corentin450
Corentin450 wrote:

Hi, you can also try Simulome, it is quite customisable.

https://github.com/price0416/Simulome

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870732/

ADD COMMENTlink written 15 months ago by Corentin450
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