I have one .vcf file of whole genome sequencing of tumour Vs normal samples of 21 patients.
I need a data from like this as input for a tool for finding driver genes
> head(mutations) sampleID chr pos ref mut 1 Sample_1 1 871244 G C 2 Sample_1 1 6648841 C G 3 Sample_1 1 17557072 G A 4 Sample_1 1 22838492 G C 5 Sample_1 1 27097733 G A 6 Sample_1 1 27333206 G A
In separated .vcf files for each patient I have start, end, chromosome, ref, and variant allele. However I am sure how to get such data frame from this big vcf
Any help please?