putative mosaic mutations
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3.4 years ago
lait ▴ 160

Hi,

I have trio WES data for mothers, fathers and children with cancer. I have detected potential denovo mutations in children using varscan trio mode.

I am looking now for potential mosaic mutations in the child, Can I consider the denovo mutations with AF < 0.3 in the child and AF = 0 in both parents to be putative mosaic mutations ? I am trying to filter down my set of putative mosaic mutations, in order to move to the next step and validate them. (note: minimum coverage is 60x)

Many thanks in advance.

mosaic de novo wes sequencing • 748 views
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