Job:We are seeking a Scientist II/Sr. Scientist in Bioinformatics!
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5.3 years ago

Scientist II/Sr. Scientist, Bioinformatics

About Morphic Therapeutic

Morphic Therapeutic is a biotechnology company developing a new generation of oral integrin therapies. Drawing on integrin biology breakthroughs from the lab of noted entrepreneur and scientific founder Tim Springer, Morphic has developed an exclusive platform to build on these discoveries, complemented by a partnership with computational chemistry leader Schrödinger, Inc., that facilitates the rapid and iterative design of clinical candidates. Morphic was created in 2015 with support from Timothy Springer, PhD, Polaris Partners, Schrödinger Inc., and ShangPharma and raised $51.5M in 2016 from top tier investors. In September 2018, Morphic Therapeutic completed an $80 million Series B financing round to advance multiple programs into the clinic. Additionally, in the last 3 months, the company has forged two transformational partnerships with Abbvie and Janssen that include >$100M upfront with future milestones. Integrins are involved in multiple disease areas, including inflammation, fibrosis, vascular diseases and cancer, and inhibitors are clinically validated. The combination of Morphic’s deep Integrin expertise with your skills will enable a rapid path to novel and effective drugs for both orphan and blockbuster indications. Morphic’s laboratories are located in the AstraZeneca BioHub in Waltham, MA. We seek a highly talented and motivated scientist to join our culture of teamwork, craftsmanship, tenacity, compassion, and integrity!

Job Description:

Morphic is currently seeking a highly motivative and experienced bioinformatics scientist to work on a variety of genomics projects in the field of autoimmunity, immune-oncology, and fibrosis. This position will work on multiple internal and external datasets for target discovery and hypothesis generation.


A successful candidate will join our highly collaborative multi-functional team and use a variety of computational algorithms and tools for the discovery of new targets. Primary responsibilities will be to:

  • Develop or apply new tools, algorithms, and data mining techniques for the integrative analysis of large genomic datasets, including but not limited to single cell RNAseq and human genetics data, from both internal and external data sources.
  • Extract information and knowledge from multi-dimensional genomics data-sets and annotations
  • Develop and implement innovative analysis strategies to generate meaningful hypotheses for new therapeutic targets or mechanism of actions of drug candidates
  • Prioritize targets and contribute to target validation study designs


  • Ph.D. in Bioinformatics, Biology, or equivalent, with a minimum of 3 years of working experience in computational biology and genomics in academia or industry.
  • A strong scientific and technical background in biology (preferably in immunology) and NGS (preferably in single cell genomics).
  • Familiarity with biological pathways and network analyses
  • Proficiency with R, Python or other scripting language for statistical computing and graphics.
  • Proven ability to analyze complexed datasets and transform information to knowledge.
  • Ability to develop intuitive visualization tools for large datasets.
  • Familiarity with cutting-edge bioinformatic and computational tools
  • Highly independent with demonstrated strong scientific curiosity
  • Effective communication skills with strong ability to explain computational approaches and data to non-computational scientists

Preferred but not required:

  • Experience in relational databases
  • Hands-on experience with machine learning algorithms and data mining methods
  • Experience in using NGS data to assess antibody library diversity and affinity maturation

Apply from our website

Morphic Therapeutic is an equal opportunity employer committed to providing an environment that maximizes our employees’ development and achievement goals. We strive to treat each employee as an individual, as we seek to foster a spirit of teamwork to help change patients’ lives. In addition to a competitive compensation and benefits package that includes medical, dental and vision coverage, a 401K and a generous vacation and holiday schedule.

RNA-Seq • 1.6k views
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for international applicants: This post seems to be for US citizens or those with US work permit as understood from the company's web site (refer to the online application form for the job)


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