evolution of gene
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3.4 years ago
Learner ▴ 250

Is there someone who could explain me what to understand from this graph?

http://phylomedb.org/?q=search_tree&seqid=Q04207

Actually I know that it is about the evolution of gene. but how they are linked?

genome • 792 views
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How is what linked?

What is the actual question here?

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@jrj.healey actual question. how the evolution of this specific gene happened

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The only useful information I can see on that tree is that they have labelled speciation and duplication events. You can't determine those from the tree alone, so there must be 'background' data under consideration for that label.

"How the evolution of a gene happened" is an unanswerable question because we don't have sequences corresponding to the deep nodes of the tree. All you can say is how the sequences at the tips differ from each other, and if they do indeed have some other information, you can talk about how a duplication may have given rise to a particular clade or similar.

What you're asking isn't really a meaningful question in my view.

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I agree @jrj.healey, the evolution of a gene happened is an unanswerable question, but there must be a natural selection process in which the ancestral unstructured gene should have acquainted with mutations and structuration for the origin of new gene with further fixation of favorable alleles in a population. This reference may help us to understand further about the origination of a new gene: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281893/

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@pltbiotech_tkarthi thanks a lot for sharing, I am going to read that manuscript

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All the best @Learner, through your question I am also learning, thanks for your question about the concept of new gene evolution!

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@ jrj.healey THANKS for your constructive message

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how ... evolution ... happened

That's a pretty broad question. The tools seems to tell you how the gene can be traced back to a common ancestral gene. What do you mean by "how"? Are you looking for each mutation and the time period that mutation was "accepted"?

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@RamRS do you know how one could look at the mutation occurrences? Wow that is fascinating

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3.4 years ago
h.mon 34k

Actually I know that it is about the evolution of gene. but how they are linked?

Actually, no, the tree is showing the evolution of a gene family, comprising orthologous and paralogous genes. Paralogous genes arise by duplications within a genome, indicated by red bifurcations at the tree, and orthologous genes arise by speciation, indicated by blue bifurcations.

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Also explained in detail in online help: http://phylomedb.org/help3

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