I am working with VEP and I found this interesting plugin: dbNSFP. Based on VEP instructions:
Release 3.5a of dbNSFP uses GRCh38/hg38 coordinates and GRCh37/hg19
To use plugin with GRCh37/hg19 data:
wget ftp://dbnsfp:firstname.lastname@example.org/dbNSFPv3.5a.zip unzip dbNSFPv3.5a.zip head -n1 dbNSFP3.5a_variant.chr1 > h cat dbNSFP3.5a_variant.chr* | grep -v ^#chr | awk '$8 != "."' | sort -k8,8 -k9,9n - | cat h - | bgzip -c > dbNSFP_hg19.gz tabix -s 8 -b 9 -e 9 dbNSFP_hg19.gz
I noticed that now the current version of the DB is 4.0.
Can I operate the same conversion as stated for the 3.5? Or shall I use this older version with less data available?
Thanks in advance for any help!