Entering edit mode
5.0 years ago
Makplus T
▴
100
I am doing some analysis about identify the driver mutation, and what tool I choose is MutSigCV, because it is from broadinsititude. But I met some problem:
where can I get the detailed about how MutSigCV actually calculates the background mutated rate (BMR)? I wonder if it calculate the rate for each patient or base on the population?
As claimed in their website, MutSigCV now support hg18 or hg19 version of genome, so if I have to deal it with hg38, as the most data is based on this version, what sould I do?
Thanks for any suggestion.