Job:Postdocs/Scientists: Long Reads, Epigenomes and Human Diseases
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4.4 years ago
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Job description: Multiple positions are available at the Mount Sinai School of Medicine (Top-20 medical school in the US) in New York City. Our lab is in the Department of Genetics and Genomic Sciences and the Institute for Genomics and Multi-scale Biology.

Our lab (computation + experiment) pioneered the fast growing field of bacterial epigenomics (Nature Biotechnology, 2012; Nature Reviews Genetics, 2018). We also pioneered the use of DNA methylation for high resolution microbiome analysis (Nature Biotechnology, 2018). In addition, we contributed to the discovery of a novel form of DNA methylation (6mA) in mammalian genomes (Nature, 2016; Genome Research, 2018). We have unique expertise in the use of third generation sequencing (Single Molecule Real-Time by PacBio, ~20kbp read length, and the emerging Oxford Nanopore sequencing technology).

Recent publications: Nature Reviews Genetics, 2018 Nature Biotechnology, 2018 Genome Research, 2018 Nature, 2016 Cell Reports, 2016 Nature Communications, 2015 PLoS Genetics, 2015 Biological Psychiatry, 2015 Nature Communications, 2014 Molecular Psychiatry, 2014 PLoS Genetics, 2013 PLoS Computational Biology, 2013 Nature Biotechnology, 2012 * Genome Research, 2012.

Lab page with details:

We are looking for highly motivated candidates for multiple PostDoc Fellow positions on the topics of Epigenomics, Trancriptomics, Microbiome analysis for Systems Biology and Precision Medicine. Three research sub-directions

1) Pathogen epigenomics, epigenetics for the discovery of novel regulators and drug targets in pathogens and their interactions with human. 2) Human Microbiome. Novel technology for, and its applications to, high resolution characterization of gut microbiome and its important roles in human disease. 3) Cancer and brain epigenetics. Novel technology for the mapping 6mA in eukaryotic genomes and functional characterization of its functional roles in human diseases.

Successful candidates will have unique opportunities to i) build on our unique expertise in third-generation long read sequencing, large scale collection of clinically relevant samples and a strong network of collaborators, ii) take the lead role in projects developing cutting edge, pioneering genomic and epigenomics technologies in the context of innovative applications with high biological, biomedical and clinical impact. Compensations for successful candidates are highly competitive. Subsidized housing (in New York City) is also available.

Requirements: 1a) Candidates with computational background are expected to have solid training in bioinformatics, genomics, epigenomics transcriptomics, or metagenomics, 2) Experimental skills are a plus, but not required, 3) Ability to learn and master new technologies and skills, 4) Abilities to lead an independent research direction while adapting to a collaborative environment, 5) An innovative yet critical thinker.

How to apply: Please send the following to 1) A brief cover letter, 2) CV with a list of publications, 3) PDF files for the papers in which you are first or co-first author.

Thank you for the interests!

Gang Fang, Associate Professor, Genetics and Genomics, Icahn School of Medicine at Mount Sinai

Key words: long read sequencing, epigenomics, DNA methylation, metagenomics, transcriptomics, systems biology, microbiome, human diseases, pathogen, infectious diseases, cancer, Alzheimer diseases, diabetes.

RNA-Seq long-reads epigenomics ChIP-Seq • 1.8k views

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