Simulate 1, 3 Copies

Question

[Ann]

Dear all,

Is there any tools that can simulate 1, 3, 7..CNVs?

Thanks!

Ann

[Damian Kao]

simulate reads? you need to provide more information on what it is you want to simulate.

Answer 1

[Neilfws]

I suggest you search Google and/or PubMed for the terms "copy number variation" and "simulated data." There is a lot of literature on CNV detection and the authors often generate simulated data in order to test their algorithms. A good article will give details of the simulation process.

Answer 2

[Ann]

Thanks!

@DK: Sorry! I didn't give enough information, simulating paired-end reads.

I inserted and deleted some regions of fasta files to make CNVs of genes; after that Wgsim to simulate.

But I'd like to look for a software making real CNVs, especially: heterogeneous copy numbers.

[biobot 0.0.77.a.1099]

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