Question: Max/min value of enrichment score
gravatar for runningonempty
16 months ago by
runningonempty10 wrote:

Hi all,

We've been discussing lately about if the enrichment score (ES), not the normalized (NES), can have values higher that 1 and lower than -1. I've done several tests using fgsea (R, package) and I never get an ES out of the range of the range of [1,-1].

Is it possible to get an ES outside this range? If this is possible, when can an ES be outside this range.

Thanks all for your time.

gsea • 442 views
ADD COMMENTlink modified 15 months ago by alserg560 • written 16 months ago by runningonempty10
gravatar for alserg
15 months ago by
alserg560 wrote:

No, it's not possible. The maximal and minimal ES values are exactly 1 (when the selected genes are exactly the top up-regulated) and -1.

You can check out the section "4.1 Geometric interpretation of GSEA statistic" of fgsea preprint ( for the better understanding on why it is so.

ADD COMMENTlink written 15 months ago by alserg560
Please log in to add an answer.


Use of this site constitutes acceptance of our User Agreement and Privacy Policy.
Powered by Biostar version 2.3.0
Traffic: 840 users visited in the last hour