Question: Max/min value of enrichment score
1
gravatar for runningonempty
16 months ago by
runningonempty10 wrote:

Hi all,

We've been discussing lately about if the enrichment score (ES), not the normalized (NES), can have values higher that 1 and lower than -1. I've done several tests using fgsea (R, package) and I never get an ES out of the range of the range of [1,-1].

Is it possible to get an ES outside this range? If this is possible, when can an ES be outside this range.

Thanks all for your time.

gsea • 442 views
ADD COMMENTlink modified 15 months ago by alserg560 • written 16 months ago by runningonempty10
0
gravatar for alserg
15 months ago by
alserg560
alserg560 wrote:

No, it's not possible. The maximal and minimal ES values are exactly 1 (when the selected genes are exactly the top up-regulated) and -1.

You can check out the section "4.1 Geometric interpretation of GSEA statistic" of fgsea preprint (https://www.biorxiv.org/content/10.1101/060012v1.full) for the better understanding on why it is so.

ADD COMMENTlink written 15 months ago by alserg560
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