Although this question is found around in some forms, I am wondering about a specific example.
There is an undecided distance around the TSS in which one can look for promoters, and that is usually several kb upstream and some distance in the first exome. I get the difficulty in giving the precise number, but I have run into the paper here which gave a promoter for LAMA4 with CpGs between +5312 to +5669 from TSS.
This seemed too far, so I started snooping around and found the following GeneCards data: https://www.genecards.org/cgi-bin/carddisp.pl?gene=LAMA4 Here we can see there are promotors in both directions at +20.1kb and -44kb. The gene is large but this still seems too much.
I would very much like a meaningful comment on the whole matter: 1) Are the values reasonable? +5K? +20K? -44K? 2) This promoter/enhancer, is there an overlap between those I wasn't aware of? Can a faraway enhancer be in anyway confused with a promotor?