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5.9 years ago
vaish01kv
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0
I'm trying to annotate vcf file obtained manualy. Can someone please help me with the algorithm that is behind most of the annotation tool like annovar, SnpEff, VEP & other annotation tools?
Thank you so much. This is so crisp & clear. It would be even more helpful if you can help me with questions like i) where exactly databases like 1000g plays a role? ii) calculating pathogenicity score & iii) inferring allele frequency from info field.
Could you please elaborate? Also it would be really helpful if you get me any journal explaining this.