Question: inherited cancer gene
gravatar for Leon
16 months ago by
Leon110 wrote:

Hello, I wanna design a panel to detect inherited caner(e.g inherited breast cancer) gene variation, but I have no idea about how to find these relatived genes. Any suggestion will be appreciated. Thank you

cancer wes • 250 views
ADD COMMENTlink written 16 months ago by Leon110
gravatar for
16 months ago by
prabin.dm190 wrote:

There are many such panels available and published. Oncotype Dx is one I can think of, and here is some from pubmed.

ADD COMMENTlink written 16 months ago by prabin.dm190

any web site can provide such genes?

ADD REPLYlink written 16 months ago by Leon110
gravatar for Kevin Blighe
16 months ago by
Kevin Blighe66k
Kevin Blighe66k wrote:

Just search online - the genes included in the panel may be listed in the original publications.

Oncotype Dx® and MammaPrint® were developed from gene expression studies, and that is what they measure.

For re-sequencing panels for hereditary cancer, there are many, such as:

  • Illumina® TruSight Cancer Sequencing panel (gene list Here (Excel file)
  • AmpliSeq™ Inherited Cancer Research Panel for Illumina®

Those are for cancer, generally; for breast cancer, here is one option:

  • AmpliSeq™ for Illumina® BRCA Plus, Extended Hereditary Breast and Ovarian Research Panel

You can also look at the panels from my former lab:

Others who I know who develop re-sequencing panels have been working in their respective field for many years and know the genes off by heart. It seems that you are not even from a breast cancer background...?

ADD COMMENTlink modified 16 months ago • written 16 months ago by Kevin Blighe66k
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