I'm curious about the calculation of drug synergy, I'm novice in these field. I would like to know how to calculate the synergy score between two drugs using one of these methods: Loewe Additivity, Highest Single Agent, Response Additivity, Bliss Independence or ZIP. Is there any implementation in Python?
Another doubt is related to data input. Is there a drug database that contains information about the mininum effective dose, maximum tolerated dose, effective dose, letal dose and the possible concentrations of drugs?
Finally, how to calculate drug reponse between two drugs?
Does anyone have an idea?