I have two questions regarding the different scores of centralities and the way to calculate them.
First one is, every one uses connectivity (or degree), is that that simple to identify hub genes ? Why not using other scores such as closeness and betweeness ?
Second question is, is it meaningflu to calculate centrality scores in subnetworks (for instance in highly correlated genes networks ie setting a threshold of correlation and only considering this subnetwork).
Thank you !