Question: centrality scores in network
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gravatar for hennet.lauriane
14 months ago by
hennet.lauriane40 wrote:

Hi,

I have two questions regarding the different scores of centralities and the way to calculate them.

First one is, every one uses connectivity (or degree), is that that simple to identify hub genes ? Why not using other scores such as closeness and betweeness ?

Second question is, is it meaningflu to calculate centrality scores in subnetworks (for instance in highly correlated genes networks ie setting a threshold of correlation and only considering this subnetwork).

Thank you !

ADD COMMENTlink modified 14 months ago • written 14 months ago by hennet.lauriane40
0
gravatar for Jean-Karim Heriche
14 months ago by
EMBL Heidelberg, Germany
Jean-Karim Heriche23k wrote:

1- By definition, a hub is a node with high degree (how high is defined by the user). So if that's what you are interested in, that's what you look for. Nodes with high betweenness or closeness centrality can have a low degree and so may not meet the requirement for being a hub.
2- It depends on the question you want to address.

ADD COMMENTlink modified 14 months ago • written 14 months ago by Jean-Karim Heriche23k
0
gravatar for hennet.lauriane
14 months ago by
hennet.lauriane40 wrote:

Thank you Jean-Karim,

I don't understand how different the biological question can be between the full network and a subnetwork of higly correlated genes. I only work with highly correlated genes to be more certain of the link between the genes...

ADD COMMENTlink written 14 months ago by hennet.lauriane40
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