I used WGCNA for finding modules. I found 9 modules: turquoise(1501), red(173), pink(41), magenta(36), grey(6), green(446), brown(348), blue(382),black(67). Based on Univariate Cox Model just turquoise is significance. The number of 1501 genes in turquoise module is high and I have to filter more for Gene Enrichment Analysis (GEA) and finding significant pathway. So, how can I decrease the number of genes in turquoise module? Generally, is it reasonable that I run a new clustering into turquoise module?
I appreciate if anybody shares his/her comment with me.