Question: Drug targets for hub genes
gravatar for banerjeeshayantan
7 months ago by
banerjeeshayantan150 wrote:

I have done differential expression analysis after which I have constructed the PPI network using the list of DEGs and then used Cytoscape to find the list of hub genes. Now how can I validate that these hub genes and the network that they form is indeed implicated in the disease I am studying. I also read that PPI network formed by hub genes can be used a prime drug targets. Is there any database that will take in the hub gene network and give us a list of drugs that might be used to target them?

rna-seq R • 250 views
ADD COMMENTlink written 7 months ago by banerjeeshayantan150

Have you tried Open Targets? With your hub genes individually.

ADD REPLYlink modified 7 months ago • written 7 months ago by genomax78k

thanks for the suggestion. I will look into that. Can you also please suggest some other methods to validate?

ADD REPLYlink written 7 months ago by banerjeeshayantan150
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